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NEUROLOGY 1987;37:847
© 1987 American Academy of Neurology

IgG synthesis rate in evaluation of multiple sclerosis in a community hospital

Eric L. Matteson, MD, David G. Flagler, MD and Bruce W. Mesara, MD

Southwestern Michigan Area Health Education Center, Kalamezoo, MI.

We obtained CSF and serum from 21 patients with definite MS in a community hospital. Ninety percent of patients had an elevated IgG synthesis rate, comparable with the sensitivity of oligoclonal bands (0.95) or the IgG index (0.90) and better than the IgG% (0.47) in definite MS. We found that no area hospital routinely employs the IgG synthesis rate. The low-sensitivity I% and the dimensionless IgG index can be abandoned. The linear IgG synthesis rate and oligoclonal band scanning should be the CSF testa of choice.

Address correspondence and reprint requests to Dr. Matteson, 3138 Chelsea Circle, Ann Arbor, MI 48104.

Received May 8, 1986. Accepted for publication in final form October 20, 1986.






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