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Oligoclonal IgG in tears

Departments of Neurology and Ophthalmology, Health Sciences Center, SUNY at Stony Brook, NY.

We examined tears from patients with MS and systemic or eye diseases, and normal controls. Tears were isoelectrofocused on agarose gel, silver-stained, and immunofixated for IgG. In the cathodal portion of the gel (pH 8.3), oligoclonal bands were detected in 14 of 21 (67%) MS tear samples. In most cases, these bands were not present in serum. Only 1 of 26 non-MS subjects showed two faint IgG tear bands, which were strongly present in serum. It appears that oligoclonal IgG bands can be detected in tears as well as in CSF of MS patients.

Address correspondence and reprint requests to Dr. Coyle, Departments of Neurology and Ophthalmology, Health Sciences Center, SUNY at Stony Brook, Stony Brook, NY 11794.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Supported by the National Eye Institute (EY 05736), National Multiple Sclerosis Society, and Teacher Investigator Development Award (NS-00790) from the NINCDS (Dr. Coyle).

Received February 14, 1986. Accepted for publication in final form August 27, 1986.