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NEUROLOGY 1987;37:856
© 1987 American Academy of Neurology

3–0-methyldopa and motor fluctuations in Parkinson's disease

G. Fabbrini, MD, J. L. Juncos, MD, M. M. Mouradian, MD, C. Serrati, MD and T. N. Chase, MD

Experimental Therapeutics Branch, National Institute of Neurological and communicative Disorders and Stroke, Bethesda, MD.

High plasma levels of 3–0-methyldopa (OMD) were found in parkinsonian patients chronically treated with levodopa, particularly in those with on-off phenomenon. However, no relation could be established between circulating levels of the levodopa metabolite and the presence of motor response fluctuations at any stage of disease. It appears unlikely that plasma OMD accumulation contributes to the pathogenesis of wearing-off or on-off responses.

Address correspondence and reprint requests to Dr. Chew, NINCDS/NIH, Building 10, Room 5C103, 9000 Rockville Pike, Bethesda, MD 20892.

Received June 17, 1986. Accepted for publication in final form August 27, 1986.






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