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Physostigmine improves ECT-induced memory disturbances

Shelvata Psychiatric Hospital, Hod Hasheron and the Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.

Electroconvulsive therapy (ECT) induces transient confusion and amnesia. Using a double-blind crossover method, we studied the influence of physostigmine on ECT-induced memory disturbances. We found that physostigmine reverses the impairment of verbal and visual short- and long-term memory after ECT. Immediate recall was neither impaired by ECT nor improved by physostigmine.

Address correspondence and reprint requests to Dr. Korczyn, Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received April 24, 1986. Accepted for publication in final form September 5, 1986.

This article has been cited by other articles:

				B. R. Sommer, A. Satlin, L. Friedman, and J. O. Cole Glycopyrrolate Versus Atropine in Post-ECT Amnesia in the Elderly J Geriatr Psychiatry Neurol, January 1, 1989; 2(1): 18 - 21. [Abstract] [PDF]