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NEUROLOGY 1987;37:881
© 1987 American Academy of Neurology

Flunarizine- and cinnarizine-induced extrapyramidal reactions

F. Micheli, MD, M. F. Pardal, MD, M. Gatto, MD, M. Torres, MD, G. Paradiso, MD, I. C. Parera, MD and R. Giannaula, MD

Hospital de Clinicas, Neurology Department, Buenos Aires, Argentina.

Cinnarizine and flunarizine are selective calcium blockers that have been used to treat and prevent vertigo. We studied 15 patients who had extrapyrqmidal syndromes after taking these drugs. Eleven patients had parkinsonism, one with persistent akathisia as well; one had an orofacial tremor; one, acute akathisia alone; and one an acute dystonic reaction. All but one improved when the drug therapy was discontinued. Seven patients were also depressed during treatment. Cinnarizine and flunarizine must therefore be added to the list of potentially risky drugs known to induce extrapyramidal reactions and depression.

Address correspondence and reprint requests to Dr. Micheli, Hospital de Clinicas, Catedra de Neurologia, Olleros 2240 (1426) Capital Federal, Buenos Aires, Argentina.

Received April 7, 1986. Accepted for publication in final form August 12, 1986.




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