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NEUROLOGY 1987;37:1001
© 1987 American Academy of Neurology

Oxytocin in Alzheimer's disease

Postmortem brain levels

Michael F. Mazurek, MD, M. Flint Beal, MD, Edward D. Bird, MD and Joseph B. Martin, MD, PhD

Department of Neurology, Massachusetts General Hospital and Harvard Medical School. Boston, MA.

Oxytocin (OXY) injected into the hippocampus is reported to interfere with the formation of memory in experimental animals. Memory impairment is one of the distinguishing features of Alzheimer's disease. We have studied OXY immunoreactivity in postmortem brain tissue from 12 cases of histologically confirmed Alzheimer's disease and 13 controls. OXY concentration was increased 33 % in the hippocampus and temporal cortex of Alzheimer brains (p <0.05), but normal in all other regions examined. Elevated hippocampal OXY levels may contribute to the memory disturbance associated with Alzheimer's disease.

Address correspondence and reprint requests to Dr. Mazurek, Neurology 4U2, McMaster University Medical Center, Hamilton, Ontario, Canada L8N 325.

Presented in part at the thirth-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Supported by NIH grants NS 16367, NIA PSOAG051134, and MH/NS 36182, and the Edward D. Cale Fund (to E.D.B.). M.F. Mazurek is a Fellow of the Medical Research Council of Canada. M.F. Beal is supported by Young Investigator Award IR23NS19867–1.

Received March 5, 1986. Accepted for publication in final form September 19, 1986.




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Physiol Rev, April 1, 2001; 81(2): 629 - 683.
[Abstract] [Full Text] [PDF]


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