Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Duffy, F. H.
Right arrow Articles by Weintraub, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Duffy, F. H.
Right arrow Articles by Weintraub, S.
NEUROLOGY 1987;37:1015
© 1987 American Academy of Neurology

Lecithin

Absence of neurophysiologic effect in Alzheimer's disease by EEG topography

F. H. Duffy, MD, G. McAnulty, PhD, M. Albert, PhD, H. Durwen, MD and S. Weintraub, PhD

Department of Neurology (Drs. Duffy and McAnulty), Children's Hospital, the Departments of Psychiatry and Neurology (Dr. Albert), Massachusetts General Hospital, Division on Aging, and the Department of Neurology (Dr. Weintraub), Beth Israel Hospital, and Harvard Medical School, Boston, MA; and the Neumhirurgische Klinik du Universitat Bonn (Dr. Durwen), Bonn, West Germany.

Ten patients with Alzheimer's disease participated in a 26-week double-blind trial of lecithin. EEG data were recorded at baseline, after administration of the placebo, and after administration of the drug. Topographic maps of EEG spectra were compared when patients were on and off drugs. A direct comparison of drug and nondrug data was not significant. A second approach, comparing differences between drug and nondrug with differences between the two nondrug conditions, also produced no evidence of a drug treatment effect. The data confirm other reports that lecithin has no effect upon spectrally analyzed EEG activity in Alzheimer's disease.

Address correspondence and reprint requests to Dr. Duffy, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115.

Supported in part by funds from the National Institute on Aging grant Po1-AGO4953 and NICHD grants HD13420 and HD06276.

Received June 23, 1986. Accepted for publication in final form September 19, 1986.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by AAN Enterprises, Inc.