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NEUROLOGY 1987;37:1054
© 1987 American Academy of Neurology

Monoclonal Paraproteinemia with subacute encephalopathy, seizures, and scleromyxedema

T. L. Reid, MD, D. V. Spoto, MD, G. J. Larrabee, PhD, M. A. Shlamowitz, MD and S. A. Horowitz, MD

Departments of Neurology, Psychiatry, and Pathology, James A. Haley Veterans Hospital, and the University of South Florida College of Medicine, Tampa, FL.

For 3 months, a 37-year-old man developed memory loss and personality changes, followed by fever, seizures, bilateral upper motor neuron signs, and increased CSF protein with skin induration that was compatible with scleromyxedema. An IgG-type paraproteinemia was identified. He improved with plasmapheresis, but died in acute respiratory and renal failure. Autopsy revealed right temporal demyelination and meningeal inflammation.

Address correspondence and reprint requests to Dr. Reid, Division of Neuropsychiatry, University of South Florida, Box 14, 12901 North 30th Street, Tampa, FL 33612.

Received June 18, 1986. Accepted for publication in final form September 19, 1986.




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