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NEUROLOGY 1987;37:945
© 1987 American Academy of Neurology

Acute trimethyltin limbic-cerebellar syndrome

R. Besser, MD, G. Krämer, MD, R. Thümler, MD, J. Bohl, MD, L. Gutmann, MD and H. C. Hopf, MD

Departments of Neurology (Drs. Besser, Krämer, and Hopf) and Neuropathology (Dr. Bohl), University of Mainz, Mainz, West Germany; the Department of Neurology (Dr. Thümler), Landesnervenklinik, Alzey, West Germany; and the Department of Neurology (Dr. Gutmann), West Virginia University School of Medicine, Morgantown, WV.

An acute limbic-cerebellar syndrome was seen in six industrial workers who inhaled trimethyltin (TMT). Clinical features included hearing loss, disorientation, confabulation, amnesia, aggressiveness, hyperphagia, disturbed sexual behavior, complex partial and tonic-clonic seizures, nystagmus, ataxia, and mild sensory neuropathy. Severity paralleled maximal urinary organotin levels. One patient died and two remained seriously disabled.

Address correspondence and reprint requests to Dr. Besser, Department of Neurology, University of Mainz, Langenbeckstrasse, 6500 Mainz, West Germany.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received July 1, 1986. Accepted for publication in final form September 19, 1986.




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