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NEUROLOGY 1987;37:993
© 1987 American Academy of Neurology

Concepts of absence epilepsies

Discrete syndromes or biological continuum?

Samuel F. Berkovic, MD, FRACP, Frederick Andermann, MD, FRCP(C), Eva Andermann, MD, PhD and Pierre Gloor, MD, PhD

Montreal Neurological Institute and Hospital, and the Department of Neurology and Neurosurgery, McCill University, Montreal, Quebec, Canada.

There are two current approaches to the clinical conceptualization of the generalized epilepsies. The syndromic approach attempts to subdivide the patient population into relatively homogeneous groups, largely on the basis of clinical and EEG criteria. In contrast, the neurobiological approach aims to formulate a unique profile for each patient by incorporating particulars of the patient onto the background of knowledge regarding the etiologic factors important in generalized epilepsy. The value of these two approaches is discussed with regard to the dual aims of, first, improving the understanding of generalized epilepsy, and second, providing a precise diagnosis, an accurate prognosis, and optimal treatment for the patient.

Address correspondence and reprint requests to Dr. F. Andermann, Montreal Neurological Institute and Hospital, 3801 University Street, Montreal, Quebec, Canada H3A 2B4.

Dr. Berkovic was supported by a Neil Hamilton Fairley Fellowship of the National Health and Medical Research Council of Australia.

Received July 31, 1986. Accepted for publication in final form September 19, 1986.




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