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NEUROLOGY 1987;37:1135
© 1987 American Academy of Neurology

Rate of ventricular enlargement in dementia of the Alzheimer type correlates with rate of neuropsychological deterioration

J. S. Luxenberg, MD, J. V. Haxby, PhD, H. Creasey, MBBS, M. Sundaram, BS and S. I. Rapoport, MD

Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD.

We studied twelve men and six women with dementia of the Alzheimer type (DAT) and twelve healthy men at intervals of 6 months to 5 years. In the male DAT patients, mean CT rates of enlargement of third ventricle and of total lateral ventricular volumes differed significantly from zero and exceeded respective control values (p < 0.05). The rate of neuropsychological decline correlated with rates of enlargement of the third ventricle or right lateral ventricle. Women with DAT also had significant rates of enlargement of the third and total lateral ventricles. The rate of lateral ventricular dilatation discriminated DAT patients from controls.

Address correspondence and reprint requests to Dr. Luxenberg, Laboratory of Neurosciences, Section on Brain Aging and Dementia, National Institute on Aging, Building 10, Room 12S235B. NIH Clinical Center, Bethesda, MD 20892.

Received September 11, 1986. Accepted for publication in final form October 31, 1986.




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