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NEUROLOGY 1987;37:1173
© 1987 American Academy of Neurology

Autonomic function in parkinsonian patients relates to duration of disease

L. Ørskov, MD, J. Jakobsen, MD, E. Dupont, MD, B. de Fine Olivarius, MD and N. J. Christensen, MD

Department of Neurology, University Hospital of Aarhus and Department of Internal Medicine and Endocrinology, Herlev Hospital, Herlev, Denmark.

Autonomic functions were studied after withdrawal of all medication in parkinsonian out-patients with short and long duration of disease and in age-matched healthy control subjects. Vagal heart control and noradrenergic response to standing were impaired and related to duration of symptoms of idiopathic parkinsonism. Cholinergic function of pupil motility was unchanged. The cholinergic dysfunction of heart rate variation, therefore, could be due to a specific loss of dopaminergic neurons in the vagal motor nucleus.

Address correspondence and reprint requests to Dr. Jakobsen, Department of Neurology, Hvidovre Hospital, DK-2650 Hvidovre, Denmark.

Supported financially by Dansk Parkinsonforening.

Received June 14, 1986. Accepted for publication in final form October 24, 1986.




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