Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by So, N. K.
Right arrow Articles by Lee, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by So, N. K.
Right arrow Articles by Lee, R. E.
NEUROLOGY 1987;37:1198
© 1987 American Academy of Neurology

Delayed leukoencephalopathy in survivors with small cell lung cancer

N. K. So, MD, B. P. O'Neill, MD, S. Frytak, MD, R. T. Eagan, MD, F. Earnest, IV, MD and R. E. Lee, MD

Comprehensive Cancer Center (Drs. O'Neill, Frytak, Eagan, and Lee), and the Departments of Neurology (Drs. So and O'Neill). Oncology (Drs. Frytak, Eagan, and Lee). and Radiology (Dr. Earnest), Mayo Foundation and Mayo Medical School, Rochester, MN.

Six patients with small cell lung cancer developed a slowly progressive neurologic syndrome characterized by apathy, abulia, memory loss, gait ataxia, and corticospinal tract signs 26 to 50 months (mean, 35.2 months) after prophylactic cranial irradiation and systemic chemotherapy. In each case this was accompanied by CT and/or MRI evidence of changes in the periventricular white matter. These patients are long-term survivors (41 to 69 months) and do not have CNS metastases.

Address correspondence and reprint requests to Dr. O'Neill, The Comprehensive Cancer Center, Mayo Foundation and Mayo Medical School, Rochester, MN 55905.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received July 28, 1986. Accepted for publication in final form October 14, 1986.




This article has been cited by other articles:


Home page
 NeurologyHome page
B. P. O'Neill
Neurocognitive outcomes in primary CNS lymphoma (PCNSL)
Neurology, February 24, 2004; 62(4): 532 - 533.
[Full Text] [PDF]

Home page
 Ann OncolHome page
R. Arriagada, T. Le Chevalier, A. Riviere, P. Chomy, I. Monnet, E. Bardet, J. A Santos-Miranda, C. Le Pechoux, M. Tarayre, S. Benhamou, et al.
Patterns of failure after prophylactic cranial irradiation in small-cell lung cancer: analysis of 505 randomized patients
Ann. Onc., May 1, 2002; 13(5): 748 - 754.
[Abstract] [Full Text] [PDF]

Home page
 Neuro Oncol DukeHome page
B. P. O'Neill, C.-H. Wang, J. R. O'Fallon, J. P. Colgan, J. D. Earle, R. L. Krigel, L. D. Brown, and W. J. McGinnis
The consequences of treatment and disease in patients with primary CNS non-Hodgkin's lymphoma: Cognitive function and performance status
Neuro-oncol, July 1, 1999; 1(3): 196 - 203.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
B. Thiessen and L. M. DeAngelis
Hydrocephalus in Radiation Leukoencephalopathy: Results of Ventriculoperitoneal Shunting
Arch Neurol, May 1, 1998; 55(5): 705 - 710.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
P. Duffey, G. Chari, N. E. F. Cartlidge, and P. J. Shaw
Progressive Deterioration of Intellect and Motor Function Occurring Several Decades After Cranial Irradiation: A New Facet in the Clinical Spectrum of Radiation Encephalopathy
Arch Neurol, August 1, 1996; 53(8): 814 - 818.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
L. J. Loescher, D. Welch-McCaffrey, S. A. Leigh, B. Hoffman, and F. L. Meyskens Jr
Surviving Adult Cancers. Part 1: Physiologic Effects
Ann Intern Med, September 1, 1989; 111(5): 411 - 432.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1987 by AAN Enterprises, Inc.