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NEUROLOGY 1987;37:1201
© 1987 American Academy of Neurology

Cortical biopsy results in Alzheimer's disease

Correlation with cognitive deficits

E. M. Martin, PhD, R. S. Wilson, PhD, R. D. Penn, MD, J. H. Fox, MD, R. A. Clasen, MD and S. M. Savoy, RN

Departments of Psychology and Social Sciences (Drs. Martin and Wilson), Neurological Surgery (Dr. Penn), Neurological Sciences (Dr. Fox), Pathology (Dr. Clasen), and Surgical Nursing (Ms. Savoy), Rush-Presbyterian St. Luke's Medical Center, Chicago, IL.

Neuropsychologic and pathologic data are presented for a group of 11 patients with a clinical diagnosis of probable Alzheimer's disease (AD) according to recently proposed criteria. In all cases, the diagnosis was verified by cortical biopsy. In addition, increased cortical plaque counts were associated with greater deficits in language production and comprehension and poorer performance on an index of global mental status. These results suggest that a clinical diagnosis of AD is very accurate when patient selection is restricted to typical cases and that language deficits may provide a useful indicator of severity of disease in AD patients.

Address correspondence and reprint requests to Dr. Martin, Psychology Service (116B). Veterans Administration Medical Center, 150 Muir Road, Martinez, CA 94553.

Supported by a grant from the Intermedics-Infusaid Corporation to Drs. Penn and Fox.

Received April 14, 1986. Accepted for publication in final form October 10, 1986.




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