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NEUROLOGY 1987;37:1205
© 1987 American Academy of Neurology

Substance P-like immunoreactivity is reduced in Alzheimer's disease cerebral cortex

M. Flint Beal, MD and Michael F. Mazurek, MD

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Substance P is an undecapeptide which has been found in human cortical neurons. We measured concentrations of this peptide in Alzheimer's disease (AD) and control postmortem tissue by radioimmunoassay. Using high-performance liquid chromatography, most of the immunoreactivity from AD or control temporal cortex comigrated with synthetic standards. Significant reductions of 20 to 40% in substance P-like immunoreactivity were found in AD cerebral cortex and hippocampus, most severe in the inferior temporal gyrus. Substance P neurons or their terminals are vulnerable to the pathophysiologic process in AD.

Address correspondence and reprint requests to Dr. Beal, Neurology Research 4, Massachusetts General Hospital, Boston, MA 02114.

Supported by Alzheimer's Disease Research Center grant NIA IP 50AG05134 and grant MNINS31862 from the Brain Tissue Resource Center, McLean Hospital. M. F. Bed holds a Young Investigator Award (IR23 NS19867) and M. F. Mazurek is a fellow of the Medical Research Council of Canada.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received August 8, 1986. Accepted for publication in final form October 14, 1986.




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