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Brain calcium content in ischemic infarction

Departments of Neurology (Drs. Chen, Hsu, Hogan, Banik, and Ms. Juan) and Pathology (Dr. Balentine), Medical University of South Carolina, Charleston, SC.

Three degrees of focal ischemic infarction in the rat were created in the cerebral cortex supplied by the right middle cerebral artery, by ligation of the right middle cerebral artery and the right common carotid artery and temporary clip compression of the left common carotid artery, in succession. The postischemic accumulation of calcium in cerebral cortex of the right middle cerebral artery territory, determined by atomic absorption spectrometry, correlated with the infarct volume. The results are consistent with the hypothesis that calcium has role as a mediator in the pathogenesis of cerebral infarction.

Address correspondence and reprint requests to Dr. Hsu, Department of Neurology, Medical University of South Carolina, Charleston, SC 29425.

Dr. Chen is a recipient of a Postdoctoral Clinical Research Fellowhsip from the Medical University of South Carolina; permanent address, Department of Neurology, Chang Gung Memorial Hospital, Taipei, Taiwan. Dr. Hsu is a recipient of a Teacher-Inveatigator Development Award from NINCDS (NS00792).

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, April 1985.

Supported in part by NS 12044, NS11066, MUSC Research Fund and grant-in aid from South Carolina Heart Association.

Received May 24, 1985. Accepted for publication in final form November 6, 1986.

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