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Delayed neurotoxicity after ingestion of carbarnate pesticide

Departments of Neurology and Rehabilitation Medicine, Mount Sinai Services at Elmhurst, and the Department of Neurology, The Mount Sinai School of Medicine of the City University of New York, NY.

We studied a patient who ingested 27 gm (500 mg/kg) of carbaryl (1-naphthyl N-methylcarbamate), a popular carbamate pesticide. After he recovered from acute cholinergic toxicity, acute weakness of arms and legs was accompanied by electrophysiologic findings consistent with axonal peripheral neuropathy. Recovery began at 1 week and continued for 9 months. A similar delayed neuropathy has been described with organophosphates but not with carbamate insecticides.

Address correspondence and reprint requests to Dr. Dickoff, Department of Neurology, Columbia University, College of Physicians and Surgeons, Columbia Presbyterian Medical Center, 710 West 168 Street, New York, NY 10032.

Received September 15, 1986. Accepted for publication in final form October 28, 1986.