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Magnetic resonance brain tumor imaging in canine glioma

Departments of Neurology, Pediatrics, Radiology, Neurosurgery, and Pathology, Vanderbilt University School of Medicine, Nashville, TN.

This study investigates a canine model of experimental brain tumor. Particularly addressed was the usefulness of gadolinium contrast-enhanced MRI for differentiating brain tumor tissue from cerebral edema. Cultured canine glioma cells were injected into the left hemispheres of six adult mongrel dogs. All dogs developed brain tumors. Serum samples drawn prior to and serially after tumor inoculation showed development of antibodies reactive to the tumor. All tumors were visualized with MRI. Contrast-enhanced T₁-weighted imaging was the most sensitive with gadolinium producing tumor enhancement due to blood-brain barrier breakdown. Gross and microscopic autopsy findings correlated well with MRIs.

Address correspondence and reprint requests to Dr. Whelan, Department of Neurology, Vanderbilt University, Medical Center South, Nashville, TN 37212.

Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.

Received July 18, 1986. Accepted for publication in final form October 31, 1986.

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