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NEUROLOGY 1987;37:1250
© 1987 American Academy of Neurology

Diurnal responsiveness to apomorphine

Stephen T. Gancher, MD and John G. Nutt, MD

Departments of Neurology (Drs. Gancher and Nutt) and Pharmacology (Dr. Nutt), Oregon Health Sciences University, Portland, OR.

Many parkinsonian patients respond to l-dopa better in the morning than at other times. To explore the possibility that this phenomenon represents diurnal fluctuations in dopaminergic receptor responsiveness, we compared the effects of subcutaneously administered apomorphine during "off" periods in the mornings and afternoons in nine fluctuating patients. The duration of response and area under the time-response curve, but not the magnitude of improvement, were dose responsive. Response durations to the same dose administered in the morning and afternoon were similar, although at threshold doses three subjects responded only to the afternoon dose. These observations suggest there is no large diurnal change in striatal dopaminergic responsiveness.

Address correspondence and reprint requests to Dr. Gancher, Department of Neurology, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201.

Supported in part by grant 5-N01-RR00334-20 from the General Clinical Research Centers Branch of the Division of Research Resources, National Institutes of Health and by NRSA grant F32 NS07759-02, National Institutes of Health.

Received July 17, 1986. Accepted for publication in final form October 31, 1986.




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