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NEUROLOGY 1987;37:1253
© 1987 American Academy of Neurology

Parkinson's disease and megacolon

Concentric hyaline inclusions (Lewy bodies) in enteric ganglion cells

W. J. Kupsky, MD, M. M. Grimes, MD, J. Sweeting, MD, R. Bertsch, MD and L. J. Cote, MD

Departments of Pathology (Drs. Kupsky and Grimes), Medicine (Dr. Sweeting), Surgery (Dr. Beech), Rehabilitation Medicine (Dr. Cote), and Neurology (Dr. Cote), Columbia Presbyterian Medical Center, New York, NY.

Concentric hyaline inclusions (Lewy bodies), found in the cytoplasm of pigmented and nonpigmented neurons, are considered characteristic of idiopathic Parkinson's disease. The finding of cytoplasmic inclusions identical to Lewy bodies in ganglion cells of the colonic myenteric plexus in a patient with idiopathic Parkinson's disease and acquired megacolon suggests primary involvement of the enteric nervous system by Parkinson's disease.

Address correspondence and reprint requests to Dr. Kupsky, Department of Pathology, The Children's Hospital, 300 Longwood Avenue, Boston, MA 02115.

Received February 20, 1986. Accepted for publication in final form October 31, 1986.




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