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NEUROLOGY 1987;37:1258
© 1987 American Academy of Neurology

Skeletal myoclonus in olivopontocerebellar atrophy

Treatment with trihexyphenidyl

H. Sasaki, MD, K. Sudoh, MD, K. Hamada, MD, T. Hamada, MD and K. Tashiro, MD

Hokuyukai Neurological Hospital (Drs. Sasski, Sudoh, K. Hamada, and T. Tamada), and the Division of Neurology (Drs. Sasaki, Sudoh, and Tashiro), Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan.

We studied two patients with nonfamilial olivopontocerebellar atrophy with skeletal myoclonus. Palatal or skeletal myoclonus is probably not a coincidental finding but another manifestation of the underlying disease. In both cases, the myoclonus was suppressed by administration of trihexyphenidyl, indicating a cholinergic disorder.

Address correspondence and reprint requests to Dr. Sasaki, Hokuyukai Neurological Hospital, 4–30, 2-jo 2-chome, 24-ken, Nishi-ku, Sapporo, 063 Japan.

Received July 7, 1986. Accepted for publication in final form October 17, 1986.






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