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Bedside and electro-oculographic analysis of abnormal ocular movements in spinocerebellar degenerations

Effects of thyrotropin-releasing hormone

Department of Neurology (Drs. Yamamoto and Saito), Fujita-Gakuen Health University, School of Medicine, and Chubu National Hospital (Dr. Sobue), Japan.

We studied ocular movements in 130 patients with spinocerebellar degenerations. Patients had blurred vision (33. 3%), diplopia (40. 2%), oscillopsia (18. 6%), ocular flutter (22. 3%), rebound nystagmus (25. 4%), square-wave jerks, (29. 2%), macro square-wave jerks (6. 2%), and macro saccadic oscillations (10. 8%). Electro-oculographic abnormalities included reduction of saccadic velocity, dysmetria, and saccadic smooth pursuit. All the abnormal movements were improved by the injection of thyrotropin-releasing hormone.

Address correspondence and reprint requests to Dr. Yamamoto, Department of Neurology, Fujita-Gakuen Health University, School of Medicine, Toyoake Aichi, Japan.

Received September 15, 1986. Accepted for publication in final form March 13, 1987.

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