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NEUROLOGY 1988;38:152
© 1988 American Academy of Neurology

Asymptomatic adult Alexander's disease

Entity or nosological misconception?

Jack E. Riggs, MD, Sydney S. Schochet, Jr., MD and Jeannie Nelson, MD

Departments of Neurology and Pathology, West Virginia University School of Medicine, Morgantown, WV.

Two adults were found to have heavy deposits of Rosenthal fibers in the CNS after dying from severe systemic medical illnesses. Previously reported cases of neurologically asymptomatic adult Alexander's disease patients also had complicated systemic disease. We suggest that heavy Rosenthal fiber deposition may occur in the setting of severe medical illness and should not be classified as adult Alexander's disease.

Address correspondence and reprint requests to Dr. R I. Department of Neurology, West Virginia University Medical Center, Morgantown. WV 26506.

Presented in part at the thirty-ninth annual meeting of the American Academy of Neurology, New York, April 1987.

Received February 24,1987. Accepted for publication in final form March 31, 1987.




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