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NEUROLOGY 1988;38:19
© 1988 American Academy of Neurology

Corpus callosotomy for epilepsy.

I. Seizure effects

S. S. Spencer, MD, D. D. Spencer, MD, P. D. Williamson, MD, K. Sass, PhD, R. A. Novelly, PhD and R. H. Mattson, MD

Departments of Neurology (Drs. S. Spencer, Williamson, Novelly, and Mattson), Surgery (Drs. D. Spencer and Sass), and Psychiatry (Dr. Novelly), Yale University School of Medicine, New Haven, and the Veterans Administration Medical Center, West Haven, CT.

Twenty-two patients were analyzed 2 or more years after corpus callosum section (9 partial, 13 total). Forty-one percent had class 1 outcome (elimination of secondarily generalized and complex partial seizures), 32% had class 2 outcome (elimination of secondarily generalized seizures), and 27% had class 3 outcome (no appreciable change). Total section was twice as effective in abolishing secondarily generalized seizures as was partial section (77% versus 35%). Statistically significant associations were seen between focal CT lesions and class 1 outcome, and between IQ less than 45 and class 2 or 3 outcome.

Address correspondence and reprint requests to Dr. S. Spencer, Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510.

Received July 16, 1986. Accepted for publication in final form March 13, 1987.




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