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Corpus callosotomy for epilepsy.

II. Neurologic and neuropsychological outcome

Departments of Surgery (Drs. Sass and D. Spencer), Neurology (Drs. S. Spencer, Novelly, Williamson, and Mattson), and Psychiatry (Dr. Novelly), Yale University School of Medicine, New Haven, and the Veterans Administration Medical Center, West Haven, CT.

Eighteen uncontrolled epileptic patients had neuropsychological evaluation before and after partial or total corpus callosotomy. In patients with early-onset seizures and signs of severe unilateral CNS dysfunction, callosotomy produced no deficits and several improvements. AH patients whose language-dominant hemisphere did not control their dominant hand had impairments in some aspect of speech and language function after callosotomy. In some patients, unilateral deterioration of motor function was observed, and was associated with mild to moderate dysfunction in the contralateral hemisphere (ie, memory impairment or preexisting hemiparesis). Postoperative deficits occurred with partial, as well as total, section.

Address correspondence and reprint requests to Dr. Sass, Section of Neurological Surgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510.

Received July 16, 1986. Accepted for publication in final form March 13, 1987.

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