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NEUROLOGY 1988;38:42
© 1988 American Academy of Neurology

Immunologic studies of patients with chronic encephalitis induced by post-exposure Semple rabies vaccine

Thiravat Hemachudha, MD, Diane E. Griffin, MD, PhD, Richard T. Johnson, MD and J. Joseph Giffels, BA

Neurology Division, Department of Medicine (Dr. Hemachudha), Chulalongkorn University Hospital, Bangkok, Thailand; and the Department of Neurology (Drs. Hemachudha, Griffin, and Johnson, and Mr. Giffels), The Johns Hopkins University School of Medicine, Baltimore, MD.

Neurologic complications of brain tissue-derived rabies vaccine may be chronic or progressive. Lymphocytes and serum from three patients with this form of encephalitis were studied. Two patients had positive lymphoproliferation to purified myelin, two had antibody to white matter, and one had antibody to myelin basic protein. No patient had antibody to proteolipid protein, myelin-associated glycoprotein, or cerebroside.

Address correspondence and reprint requests to Dr. Griffin, Department of Neurology, Meyer 6-181, The Johns Hopkins Medical Institutions, Baltimore, MD 21205.

Supported by grants from the National Multiple Sclerosis Society and Chulalongkorn University, and a Fogarty Fellowship to Dr. Hemachudha.

Received December 22, 1986. Accepted for publication in final form March 18, 1987.




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