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NEUROLOGY 1988;38:81
© 1988 American Academy of Neurology

Serologic studies of MS patients, controls, and patients with other neurologic diseases

Antibodies to HTLV-I, II, III

D. L. Madden, DVM, PhD, F. K. Mundon, MS, N. R. Tzan; D. A. Fuccillo, PhD, M. C. Dalakas, MD, V. Calabrese, MD, T. S. Elizan, MD and J. L. Sever, MD, PhD

National Institute of Neurological and Communicative Disorders and Stroke (Drs. Madden, Dalakas, and Sever, and Ms. Tzan), National Institutes of Health, Bethesda; Electronucleonics (Mr. Mundon), Columbia; and Microbiological Associates (Dr. Fuccillo). Bethesda, MD; the Medical College of Virginia (Dr. Calabrese), Richmond, VA; and the Mount Sinai Medical Center (Dr. Elizan), New York, NY.

We have studied the frequency of human retrovirus antibody (HTLV-I, II, III) in the serum and CSF of patients with MS, matched controls, and patients with optic neuritis, idiopathic and postencephalitic Parkinson's disease, neuropathies, polymyositis, ALS, and postpoliomyelitis. Except for the postpoliomyelitis samples, all samples were collected prior to 1980. Contrary to a previous published report, no significant levels of antibody to HTLV-I, II, or III were found in the MS patients or controls. No retrovirus antibody was detected in patients with the other neurologic diseases.

Address correspondence and reprint requests to Dr. Madden, Section in Immunochemistry & Clinical Investigations, Building 36, Room 5D-06, National Institutes of Health, Bethesda, MD 20892.

Received November 21, 1986. Accepted for publication in final form March 10, 1987.






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