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NEUROLOGY 1988;38:1864
© 1988 American Academy of Neurology

Positron emission tomography in a patient with progressive multifocal leukoencephalopathy

M. Kiyosawa, MD, T. M. Bosley, MD, A. Alavi, MD, N. Gupta, MD, C. H. Rhodes, MD, J. Chawluk, MD, M. Kushner, MD, P. J. Savino, MD, R. C. Sergott, MD, N. J. Schatz, MD and M. Reivich, MD

Cerebrovascular Research Center of the Department of Neurology (Drs. Kiyosawa, Bosley, Chawluk, Kushner, and Reivich), Department of Radiology (Drs. Alavi and Gupta) and Pathology (Dr. Rhodes) of the University of Pennsylvania, and the Neuro-Ophthalmology Service (Drs. Kiyosawa, Bosley, Savino, Sergott, and Schatz), Wills Eye Hospital, Philadelphia, PA.

A 56-year-old man with chronic lymphocytic leukemia, progressive multifocal leukoencephalopathy, and a dense left homonymous hemianopia had 18F-fluorodeoxyglucose positron emission tomography. Cortical glucose metabolism was decreased in the right cerebral hemisphere and the left cerebellar hemisphere. To our knowledge, this is the first demonstration of cerebral and cerebellar hypometabolism due solely to white matter disease.

Address correspondence and reprint requests to Dr. Bosley, Neuro-Ophthalmology Service, Wills Eye Hospital, Ninth and Walnut Sts., Philadelphia, PA 19107.

Supported by USPHS Program Project Grant NS-14867-09. Dr. Kiyosawa is supported by Fight For Sight Fellowship E-PD-100.

Received April 6, 1988. Accepted for publication in final form June 2, 1988.






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