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Immunostaining of motor nerve terminals by IgM M protein with activity against gangliosides GM₁ and GD_lb from a patient with motor neuron disease

Laboratory of Neurobiology, Department of Neurology, Centre Hos-pitalier Universitaire Vaudois, Lausanne, Switzerland.

We demonstrated the binding of an IgM monoclonal protein, obtained from a patient with motor neuron disease, with known antibody activity against gangliosides GM₁, GD_lb, and asialo GM₁, to neuromuscular junctions in guinea pig gastrocnemius muscle, using an indirect immunofluorescence technique. Staining disappeared after delipidation of muscle sections. Denervated muscle sections showed no labeling at the neuromuscular junction after incubation with the patient's serum. This indicates presynaptic binding of the IgM M protein and supports the concept that IgM monoclonal antibody to nerve terminal determinants may underlie a motor neuron disorder.

Address correspondence and reprint requests to Dr. Steck, Department of Neurology, CHUV, 1011 Lausanne, Switzerland.

Supported by grants from the Swiss National Fund for Scientific Research and the Puccini Foundation.

Received April 4, 1988. Accepted for publication in final form June 2, 1988.

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