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NEUROLOGY 1988;38:175
© 1988 American Academy of Neurology

Magnetic resonance imaging of the optic nerve in optic neuritis

D. H. Miller, FRACP, M. R. Newton, FRACP, J. C. van der Poel, PhD, E. P. G. H. du Boulay, FRCR, A. M. Halliday, MRCP, B. E. Kendall, FRCR, G. Johnson, PhD, D. G. MacManus, DCR, I. F. Moseley, FRCR and W. I. McDonald, FRCP

From the Institute of Neurology and National Hospitals for Nervous Diseases, Queen Square, London WC1N 3BG, United Kingdom.

Magnetic resonance imaging (MRI) of the optic nerves using the STIR (short inversion time inversion recovery) sequence was performed in 37 adult patients with a recent or past attack of optic neuritis. MRI revealed high-signal regions in 84% of symptomatic and 20% of asymptomatic nerves. The mean longitudinal extent of lesions was 1 cm. Slow or poor visual recovery was associated with more extensive lesions, or lesions within the optic canal. Disk swelling was usually associated with anterior lesions but also occurred with lesions in the canal. Visual evoked potentials were even more sensitive than MRI in detecting lesions and are still the investigation of choice in suspected demyelinating disease involving the optic nerve.

Address correspondence and reprint requests to Professor McDonald, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom.

Supported in part by the Medical Research Council of the United Kingdom.

Received August 6, 1987. Accepted for publication in final form October 14, 1987.




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