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From the Veterans Administration Medical Center, San Diego, and the Departments of Neurosciences (Dr. Kritchevsky) and Psychiatry (Dr. Squire and Ms. Zouzounis), University of California, San Diego, CA.
Five patients with transient global amnesia (TGA) were given neuropsychological tests during and after their episode. During TGA, all patients were impaired on tests of new learning ability for both verbal and nonverbal material. Retrograde amnesia was patchy and covered a variable period of time before the onset of the episode: from about 36 hours in one case to 4 years in two cases. Some cognitive impairment in addition to amnesia was present during the episode. For example, patients copied a complex figure more poorly during the episode than afterwards. All patients had normal memory at follow-up testing. These data are consistent with the idea that the amnesic symptoms of TGA are caused by transient bilateral dysfunction of medial temporal brain structures important for memory.
Received February 24, 1987. Accepted for publication in final form May 13, 1987.
Address correspondence and reprint requests to Dr. Kritchevsky, VA Medical Center (127), 3350 La Jolla Village Drive, San Diego, CA 92161.
Supported by the Medical Research Service of the Veterans Administration, by NIMH grant MH24600, and by the Office of Naval Research.
Presented in part at the thirty-ninth annual meeting of the American Academy of Neurology, New York, NY, April 1987.
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