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NEUROLOGY 1988;38:239
© 1988 American Academy of Neurology

Inhibition of fatty acid beta oxidation by influenza B virus and salicylic acid in mice

Implications for Reye's syndrome

Doris A. Trauner, MD, Elizabeth Horvath, BS and Larry E. Davis, MD

From the Departments of Neurosciences and Pediatrics (Dr. Trauner and Ms. Horvath), University of California, San Diego Medical Center, San Diego, CA; and the Neurology Service (Dr. Davis), Albuquerque VA Medical Center, Albuquerque, NM.

Injection of concentrated influenza B/Lee/40 virus into 4-week-old Balb C mice resulted in 60% inhibition of 14C-palmitate oxidation in isolated hepatic mitochondria. Oral feeding of carnitine to infected mice prevented the inhibition of fatty acid oxidation. High concentrations of salicylic acid given orally also inhibited 14C-palmitate oxidation. Serum free fatty acid concentrations of infected mice and of those fed salicylic acid were significantly higher than in control mice. A combination of low-dose virus and low-dose salicylic acid inhibited palmitate oxidation, suggesting an additive effect on the metabolic derangement when the two agents were present simultaneously.

Address correspondence and reprint requests to Dr. Trauner, UCSD Medical Center H-815-B, 225 W. Dickinson Street, San Diego, CA 92103.

Supported in part by a research grant from the National Reye's Syndrome Foundation of Bryan, Ohio, and by the Research Service, Veterans Administration.

Received July 29, 1985. Accepted for publication in final form May 6, 1987.




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