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Efficacy of alprazolam for essential tremor

From the Department of Neurology, The Ohio State University College of Medicine, Columbus, OH.

The effect of alprazolam on essential tremor was examined by a double-blind, placebo-controlled parallel study of 24 patients. Results indicated that patients treated with alprazolam had significant improvement in tremor. Transient mild fatigue or sedation in 50% of patients was the primary side effect. Alprazolam may provide therapeutic benefit, especially in patients who require only intermittent therapy.

Address correspondence and reprint requests to Dr. Huber, Department of Neurology, 425 Means Hall, 1654 Upham Drive, Columbus, OH 43210.

Received December 8, 1986. Accepted for publication in final form April 30, 1987.

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