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From the Laboratory of Neurophysiology (Drs. Pullman and Watts), National Institute of Mental Health, and the Experimental Therapeutics Branch (Drs. Juncos and Chase) and Human Motor Control Section, Medical Neurology Branch (Dr. Sanes), National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD.
The present study examined whether premovement central neural processing in Parkinson's disease was related to functional motor disability and plasma L-dopa concentration. Reaction time (RT) performance in simple and choice RT tasks was assessed while plasma L-dopa levels were controlled by continuous IV L-dopa infusion in five parkinsonian patients. Five age-matched controls performed the same RT tasks for comparison. Simple RT for the patients was longer than the normal control RT at all infusion levels (p 
0. 005). However, choice RT was normal when the patients were "on," but became prolonged as plasma L-dopa levels decreased (p 0. 01). The results show that there are abnormalities of premovement central neural processing in Parkinson's disease, and that simple and choice RTs are differentially affected by L-dopa replacement. This suggests that different neural mechanisms may be involved in the processing of these tasks.
Address correspondence and reprint requests to Dr. Pullman, The Neurological Institute, Columbia-Presbyterian Medical Center, 710 West 168th Street, New York, NY 10032.
Presented in part at the thirty-eighth annual meeting of the American Academy of Neurology, New Orleans, LA, April 1986.
Received February 24, 1987. Accepted for publication in final form April 22, 1987.
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