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A double-blind trial of clonazepam in the treatment of parkinsonian dysarthria

From the Department of Neurology (Dr. Biary), Department of Physical Medicine and Rehabilitation (Dr. Pimental), and Department of Epidemiology/Biometry (Dr. Langenberg), University of Illinois at Chicago, College of Medicine, Chicago, IL.

We studied the effect of clonazepam in a double-blind trial on 12 parkinsonian patients with hypokinetic dysarthria. Speech samples were judged on 14 of the dimensions used in the Mayo Clinic dysarthria study. Of the 11 patients who completed the study, 10 showed improvement. The effective dosage of clonazepam was 0. 25 to 0. 5 mg/d with higher dosage than that less effective. Clonazepam has a definite role in the management of perkinsonian dysarthria.

Address correspondence and reprint requests to Dr. Biary, Department of Neurology, University of Illinois at Chicago, 912 S. Wood Street, Room 855 N, Chicago, IL 60612.

Received October 31, 1986. Accepted for publication in final form May 11, 1987.

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