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NEUROLOGY 1988;38:289
© 1988 American Academy of Neurology

Expression of three viral oncogenes (v-sis, v-myc, v-fos) in primary human brain tumors of neuroectodermal origin

M. Fujimoto, MD, F. J. Weaker, PhD, D. C. Herbert, PhD, Z. D. Sharp, PhD, P. J. Sheridan, PhD and J. L. Story, MD

From the Department of Surgery, Division of Neurosurgery (Drs. Fujimoto and Story) and the Department of Cellular and Structural Biology (Drs. Weaker, Herbert, Sharp, and Sheridan), The University of Texas Health Science Center at San Antonio, San Antonio, TX.

We determined which viral oncogenes (v-sis, v-myc, and v-fos) were expressed in five primary human brain tumors of neuroectodermal origin (two glioblastomas multiforme, one medulloblastoma, one cystic cerebellar astrocytoma, and one ganglioglioma) and which of these oncogenes is correlated with malignancy. Using the dot hybridization technique, we determined the relative amounts of mRNA coded by these genes using the same nitrocellulose filter. The v-myc probe showed a 4-to 12-fold greater hybridization to the mRNA from two glioblastomas and the medulloblastoma (malignant group) than the mRNA from the cystic cerebellar astrocytoma or the ganglioglioma (benign group). In contrast, RNA hybridizing to v-sis and v-fos were accumulated to a greater extent in the benign tumors. These data suggest that the amount of myc expression may be correlated with the degree of malignancy of brain tumors of neuroectodermal origin.

Address correspondence and reprint requests to Dr. Fujimoto, Department of Surgery, Division of Neurosurgery, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284.

Supported in part by grant #IN-116H from the American Cancer Society.

Received October 23, 1986. Accepted for publication in final form May 4, 1987.






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