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NEUROLOGY 1988;38:293
© 1988 American Academy of Neurology

Motor nerve ending disorder in myasthenia gravis

Robert D. Roe, MD, Walter F. Riker, MD and Frank G. Standaert, MD

From the Department of Neurology, Mt. Sinai School of Medicine (Dr. Roe), the Departments of Pharmacology and Anesthesiology, Cornell University Medical College (Dr. Riker), New York, NY; and Georgetown University School of Medicine (Dr. Standaert), Washington, DC. Dr. Standaert is currently at the Medical College of Ohio, Toledo, OH.

Mild myasthenia gravis patients were compared with normals with respect to the capacity of their motor nerve endings (MNEs) to generate a neostigmine-induced postactivation repetition (PAR). Dose-response analyses of PAR recorded from muscle electrically and by contractile measurement disclose a loss of this pharmacologic responsiveness in myasthenia. Since mild myasthenics transmitted nerve impulse trains of 20 to 200 Hz, as did normals, it was evident that PAR is transmitted insofar as it can be generated by MNEs. The dose-response analyses support this. These data indicate an MNE disorder in the disease.

Address correspondence and reprint requests to Dr. Roe, 1 Pondfield Road, Bronxville, NY 10708.

Received March 24, 1987. Accepted for publication in final form May 18, 1987.






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