HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Araki, M. Articles by Sugita, H. Search for Related Content PubMed PubMed Citation Articles by Araki, M. Articles by Sugita, H.

Neuroleptic malignant syndrome

Caffeine contracture of single muscle fibers and muscle pathology

From the Division of Neuromuscular Research (Drs. Araki, Higuchi, and Sugita), National Institute of Neuroscience, NCNP, and the Department of Neurology (Dr. Takagi), Toranomon Hospital, Tokyo, Japan.

The neuroleptic malignant syndrome (NMS) is similar to anesthesia-induced malignant hyperthermia (MH) in three major clinical features: hyperthermia, muscular rigidity, and myoglobinuria. In eight cases of NMS, we studied caffeine contracture of single skinned muscle fibers. Sensitivity of the sarcoplasmic reticulum to caffeine was abnormally increased in six of the eight cases. Morphologic studies showed type 2B fiber atrophy in all six cases examined, and there were necrotic fibers in two cases. Since skeletal muscle is affected in NMS, these patients may be susceptible to MH.

Address correspondence and reprint requests to Dr. Araki, Division of Neuromuscular Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo 187, Japan.

Supported by grant No. 85–04 from the National Institute of Neuroscience, NCNP, and a Grant-in-Aid for New Drug Development from the Ministry of Health and Welfare, Japan.

Received October 8, 1986. Accepted for publication in final form April 23, 1987.

This article has been cited by other articles:

				E. B. Ty and A. D. Rothner Topical Review : Neuroleptic Malignant Syndrome in Children and Adolescents J Child Neurol, March 1, 2001; 16(3): 157 - 163. [Abstract] [PDF]

				P. Adnet, P. Lestavel, and R. Krivosic-Horber Neuroleptic malignant syndrome Br. J. Anaesth., July 1, 2000; 85(1): 129 - 135. [Full Text] [PDF]