| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Geriatric Research Programme and the Departments of Psychology, Extended Care, and Pathology, Sunnybrook Medical Centre, University of Toronto, Toronto, Ontario, Canada.
Neuropathologic confirmation is required to validate the NINCDS-ADRDA Work Group criteria for the clinical diagnosis of Alzheimer's disease (AD). Neuropathologic inclusion and exclusion criteria for AD, however, are not uniform. The purpose of this investigation was to examine the confirmation rate for the Work Group criteria against differing neuropathologic criteria for AD. The sample consisted of 57 cases, 22 of which had received a clinical diagnosis of AD. Nine neuropathologic criteria for AD were applied in a blind fashion to each of the 57 cases. Our results indicated that, depending on the neuropathologic criteria applied, the clinicopathologic agreement ranged from 64% to 86%. These findings demonstrate the need for universally accepted neuropathologic and clinical criteria for AD.
Address correspondence and reprint requests to Dr. Tierney, Geriatric Research Programme, Sunnybrook Medical Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.
Supported by the Ontario Ministry of Health, the Gerontology Research Council of Ontario, the Canadian Geriatric Research Society, and the Sunnybrook Medical Centre Research Fund.
Received March 25, 1987. Accepted for publication in final form June 10, 1987.
This article has been cited by other articles:
|
|
 |
|
  F.L. Giesel, H.K. Hahn, P.A. Thomann, E. Widjaja, E. Wignall, H. von Tengg-Kobligk, J. Pantel, P.D. Griffiths, H.O. Peitgen, J. Schroder, et al. Temporal Horn Index and Volume of Medial Temporal Lobe Atrophy Using a New Semiautomated Method for Rapid and Precise Assessment AJNR Am. J. Neuroradiol., August 1, 2006; 27(7): 1454 - 1458. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. L. Chao, N. Schuff, J. H. Kramer, A. T. Du, A. A. Capizzano, J. O'Neill, O. M. Wolkowitz, W. J. Jagust, H. C. Chui, B. L. Miller, et al. Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients Neurology, January 25, 2005; 64(2): 282 - 289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Schuff, A.A. Capizzano, A.T. Du, D.L. Amend, J. O'Neill, D. Norman, W.J. Jagust, H.C. Chui, J.H. Kramer, B.R. Reed, et al. Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD Neurology, August 12, 2003; 61(3): 358 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J J Kril, S Patel, A J Harding, and G M Halliday Patients with vascular dementia due to microvascular pathology have significant hippocampal neuronal loss J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 747 - 751. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Schuff, A. A. Capizzano, A. T. Du, D. L. Amend, J. O'Neill, D. Norman, J. Kramer, W. Jagust, B. Miller, O. M. Wolkowitz, et al. Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD Neurology, March 26, 2002; 58(6): 928 - 935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Padovani, L. Pastorino, B. Borroni, F. Colciaghi, L. Rozzini, R. Monastero, J. Perez, C. Pettenati, M. Mussi, G. Parrinello, et al. Amyloid precursor protein in platelets: A peripheral marker for the diagnosis of sporadic AD Neurology, December 26, 2001; 57(12): 2243 - 2248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Petrovitch, L.R. White, G.W. Ross, S.C. Steinhorn, C.Y. Li, K.H. Masaki, D.G. Davis, J. Nelson, J. Hardman, J.D. Curb, et al. Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study Neurology, July 24, 2001; 57(2): 226 - 234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Andreasen, L. Minthon, P. Davidsson, E. Vanmechelen, H. Vanderstichele, B. Winblad, and K. Blennow Evaluation of CSF-tau and CSF-A{beta}42 as Diagnostic Markers for Alzheimer Disease in Clinical Practice Arch Neurol, March 1, 2001; 58(3): 373 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Hoffman, K. A. Welsh-Bohmer, M. Hanson, B. Crain, C. Hulette, N. Earl, and R. E. Coleman FDG PET Imaging in Patients with Pathologically Verified Dementia J. Nucl. Med., November 1, 2000; 41(11): 1920 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. SCHELTENS and B. KITTNER Preliminary Results from an MRI/CT-Based Database for Vascular Dementia and Alzheimer's Disease Ann. N.Y. Acad. Sci., April 1, 2000; 903(1): 542 - 546. [Full Text] [PDF]
|
|
|
|
|
|
N. Andreasen, L. Minthon, A. Clarberg, P. Davidsson, J. Gottfries, E. Vanmechelen, H. Vanderstichele, B. Winblad, and K. Blennow Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample Neurology, October 22, 1999; 53(7): 1488 - 1488. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Nobler, G. H. Pelton, and H. A. Sackeim Cerebral Blood Flow and Metabolism in Late-Life Depression and Dementia J Geriatr Psychiatry Neurol, October 1, 1999; 12(3): 118 - 127. [Abstract] [PDF]
|
|
|
|
|
|
O. L. Lopez, I. Litvan, K. E. Catt, R. Stowe, W. Klunk, D. I. Kaufer, J. T. Becker, and S. T. DeKosky Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias Neurology, October 1, 1999; 53(6): 1292 - 1292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Juottonen, M. P. Laakso, K. Partanen, and H. Soininen Comparative MR Analysis of the Entorhinal Cortex and Hippocampus in Diagnosing Alzheimer Disease AJNR Am. J. Neuroradiol., January 1, 1999; 20(1): 139 - 144. [Abstract] [Full Text]
|
|
|
|
|
|
D. Galasko, L. Chang, R. Motter, C. M. Clark, J. Kaye, D. Knopman, R. Thomas, D. Kholodenko, D. Schenk, I. Lieberburg, et al. High Cerebrospinal Fluid Tau and Low Amyloid {beta}42 Levels in the Clinical Diagnosis of Alzheimer Disease and Relation to Apolipoprotein E Genotype Arch Neurol, July 1, 1998; 55(7): 937 - 945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. V Bowler, D. G Munoz, H. Merskey, and V. Hachinski Fallacies in the pathological confirmation of the diagnosis of Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, January 1, 1998; 64(1): 18 - 24. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. Shua-Haim, G. Koppuzha, V. Shua-Haim, and J. Gross A simple score system for clock drawing in patients with Alzheimer's disease American Journal of Alzheimer's Disease and Other Dementias, September 1, 1997; 12(5): 212 - 215. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Wetterling, R.-D. Kanitz, and K.-J. Borgis Comparison of Different Diagnostic Criteria for Vascular Dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN) Stroke, January 1, 1996; 27(1): 30 - 36. [Abstract] [Full Text]
|
|
|
|
 |
|
 N.H.P. Allen and A. Burns The treatment of Alzheimer's disease J Psychopharmacol, January 1, 1995; 9(1): 43 - 56. [PDF]
|
|
|
|
 |
|
 J. R. Absher, D. L. Sultzer, M. E. Mahler, and J. Fishman p(C) Analysis Facilitates Dementia Diagnosis Med Decis Making, October 1, 1994; 14(4): 393 - 402. [Abstract] [PDF]
|
|
|
|
 |
|
 M Shoji, T. Golde, J Ghiso, T. Cheung, S Estus, L. Shaffer, X. Cai, D. McKay, R Tintner, B Frangione, et al. Production of the Alzheimer amyloid beta protein by normal proteolytic processing Science, October 2, 1992; 258(5079): 126 - 129. [Abstract] [PDF]
|
|
|
|
|
|
H. Ito, S. Goto, A. Hirano, and S.-H. C. Yen Immunohistochemical Study of the Hippocampus in Parkinsonism-Dementia Complex on Guam J Geriatr Psychiatry Neurol, July 1, 1991; 4(3): 134 - 142. [Abstract] [PDF]
|
|
|
|
|
|
K. A. Shay, L. W. Duke, T. Conboy, L. E. Harrell, R. Callaway, and D. G. Folks The Clinical Validity of the Mattis Dementia Rating Scale in Staging Alzheimer's Dementia J Geriatr Psychiatry Neurol, January 1, 1991; 4(1): 18 - 25. [Abstract] [PDF]
|
|
|
|
|
|
M. F. Mendez, A. R. Mastri, J.H. Sung, B. A. Zander, and W. H. Frey Neuropathologically Confirmed Alzheimer's Disease: Clinical Diagnoses in 394 Cases J Geriatr Psychiatry Neurol, January 1, 1991; 4(1): 26 - 29. [Abstract] [PDF]
|
|
|
|
|
|
J. Whitson, D. Selkoe, and C. Cotman Amyloid beta protein enhances the survival of hippocampal neurons in vitro Science, March 17, 1989; 243(4897): 1488 - 1490. [Abstract] [PDF]
|
|
|
|
|
|
W. A. Marks, R. M. Shuman, R. W. Leech, and R. A. Brumback Cerebral Degenerations Producing Dementia: Importance of Neuropathologic Confirmation of Clinical Diagnoses J Geriatr Psychiatry Neurol, October 1, 1988; 1(4): 187 - 198. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
