|
|
||||||||
From the Geriatric Research Programme and the Departments of Psychology, Extended Care, and Pathology, Sunnybrook Medical Centre, University of Toronto, Toronto, Ontario, Canada.
Neuropathologic confirmation is required to validate the NINCDS-ADRDA Work Group criteria for the clinical diagnosis of Alzheimer's disease (AD). Neuropathologic inclusion and exclusion criteria for AD, however, are not uniform. The purpose of this investigation was to examine the confirmation rate for the Work Group criteria against differing neuropathologic criteria for AD. The sample consisted of 57 cases, 22 of which had received a clinical diagnosis of AD. Nine neuropathologic criteria for AD were applied in a blind fashion to each of the 57 cases. Our results indicated that, depending on the neuropathologic criteria applied, the clinicopathologic agreement ranged from 64% to 86%. These findings demonstrate the need for universally accepted neuropathologic and clinical criteria for AD.
Address correspondence and reprint requests to Dr. Tierney, Geriatric Research Programme, Sunnybrook Medical Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.
Supported by the Ontario Ministry of Health, the Gerontology Research Council of Ontario, the Canadian Geriatric Research Society, and the Sunnybrook Medical Centre Research Fund.
Received March 25, 1987. Accepted for publication in final form June 10, 1987.
This article has been cited by other articles:
![]() |
F.L. Giesel, H.K. Hahn, P.A. Thomann, E. Widjaja, E. Wignall, H. von Tengg-Kobligk, J. Pantel, P.D. Griffiths, H.O. Peitgen, J. Schroder, et al. Temporal Horn Index and Volume of Medial Temporal Lobe Atrophy Using a New Semiautomated Method for Rapid and Precise Assessment AJNR Am. J. Neuroradiol., August 1, 2006; 27(7): 1454 - 1458. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. L. Chao, N. Schuff, J. H. Kramer, A. T. Du, A. A. Capizzano, J. O'Neill, O. M. Wolkowitz, W. J. Jagust, H. C. Chui, B. L. Miller, et al. Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients Neurology, January 25, 2005; 64(2): 282 - 289. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Schuff, A.A. Capizzano, A.T. Du, D.L. Amend, J. O'Neill, D. Norman, W.J. Jagust, H.C. Chui, J.H. Kramer, B.R. Reed, et al. Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD Neurology, August 12, 2003; 61(3): 358 - 364. [Abstract] [Full Text] [PDF] |
||||
![]() |
J J Kril, S Patel, A J Harding, and G M Halliday Patients with vascular dementia due to microvascular pathology have significant hippocampal neuronal loss J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 747 - 751. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Schuff, A. A. Capizzano, A. T. Du, D. L. Amend, J. O'Neill, D. Norman, J. Kramer, W. Jagust, B. Miller, O. M. Wolkowitz, et al. Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD Neurology, March 26, 2002; 58(6): 928 - 935. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Padovani, L. Pastorino, B. Borroni, F. Colciaghi, L. Rozzini, R. Monastero, J. Perez, C. Pettenati, M. Mussi, G. Parrinello, et al. Amyloid precursor protein in platelets: A peripheral marker for the diagnosis of sporadic AD Neurology, December 26, 2001; 57(12): 2243 - 2248. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Petrovitch, L.R. White, G.W. Ross, S.C. Steinhorn, C.Y. Li, K.H. Masaki, D.G. Davis, J. Nelson, J. Hardman, J.D. Curb, et al. Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study Neurology, July 24, 2001; 57(2): 226 - 234. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Andreasen, L. Minthon, P. Davidsson, E. Vanmechelen, H. Vanderstichele, B. Winblad, and K. Blennow Evaluation of CSF-tau and CSF-A{beta}42 as Diagnostic Markers for Alzheimer Disease in Clinical Practice Arch Neurol, March 1, 2001; 58(3): 373 - 379. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Hoffman, K. A. Welsh-Bohmer, M. Hanson, B. Crain, C. Hulette, N. Earl, and R. E. Coleman FDG PET Imaging in Patients with Pathologically Verified Dementia J. Nucl. Med., November 1, 2000; 41(11): 1920 - 1928. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. Andreasen, L. Minthon, A. Clarberg, P. Davidsson, J. Gottfries, E. Vanmechelen, H. Vanderstichele, B. Winblad, and K. Blennow Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample Neurology, October 22, 1999; 53(7): 1488 - 1488. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. S. Nobler, G. H. Pelton, and H. A. Sackeim Cerebral Blood Flow and Metabolism in Late-Life Depression and Dementia J Geriatr Psychiatry Neurol, October 1, 1999; 12(3): 118 - 127. [Abstract] [PDF] |
||||
![]() |
O. L. Lopez, I. Litvan, K. E. Catt, R. Stowe, W. Klunk, D. I. Kaufer, J. T. Becker, and S. T. DeKosky Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias Neurology, October 1, 1999; 53(6): 1292 - 1292. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Juottonen, M. P. Laakso, K. Partanen, and H. Soininen Comparative MR Analysis of the Entorhinal Cortex and Hippocampus in Diagnosing Alzheimer Disease AJNR Am. J. Neuroradiol., January 1, 1999; 20(1): 139 - 144. [Abstract] [Full Text] |
||||
![]() |
D. Galasko, L. Chang, R. Motter, C. M. Clark, J. Kaye, D. Knopman, R. Thomas, D. Kholodenko, D. Schenk, I. Lieberburg, et al. High Cerebrospinal Fluid Tau and Low Amyloid {beta}42 Levels in the Clinical Diagnosis of Alzheimer Disease and Relation to Apolipoprotein E Genotype Arch Neurol, July 1, 1998; 55(7): 937 - 945. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. V Bowler, D. G Munoz, H. Merskey, and V. Hachinski Fallacies in the pathological confirmation of the diagnosis of Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, January 1, 1998; 64(1): 18 - 24. [Abstract] [Full Text] |
||||
![]() |
J. Shua-Haim, G. Koppuzha, V. Shua-Haim, and J. Gross A simple score system for clock drawing in patients with Alzheimer's disease American Journal of Alzheimer's Disease and Other Dementias, September 1, 1997; 12(5): 212 - 215. [Abstract] [PDF] |
||||
![]() |
G. Li, M. Aryan, J. M. Silverman, V. Haroutunian, D. P. Perl, S. Birstein, M. Lantz, D. B. Marin, R. C. Mohs, and K. L. Davis The Validity of the Family History Method for Identifying Alzheimer Disease Arch Neurol, May 1, 1997; 54(5): 634 - 640. [Abstract] [PDF] |
||||
![]() |
K. F. Mortel and J. S. Meyer Prospective Study of Vascular Events and Cerebral Perfusional Chang Following Transient Ischemic Attacks Angiology, March 1, 1996; 47(3): 215 - 224. [Abstract] [PDF] |
||||
![]() |
L. A. Klatka, R. B. Schiffer, J. M. Powers, and A. M. Kazee Incorrect Diagnosis of Alzheimer's Disease: A Clinicopathologic Study Arch Neurol, January 1, 1996; 53(1): 35 - 42. [Abstract] [PDF] |
||||
![]() |
H. A. Crystal, D. Dickson, M. Sliwinski, D. Masur, A. Blau, and R. B. Lipton Associations of Status and Change Measures of Neuropsychological Function With Pathologic Changes in Elderly, Originally Nondemented Subjects Arch Neurol, January 1, 1996; 53(1): 82 - 87. [Abstract] [PDF] |
||||
![]() |
T. Wetterling, R.-D. Kanitz, and K.-J. Borgis Comparison of Different Diagnostic Criteria for Vascular Dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN) Stroke, January 1, 1996; 27(1): 30 - 36. [Abstract] [Full Text] |
||||
![]() |
S. Biedert, H. Forstl, and W. Hewer Multiinfarct Dementia vs Alzheimer's Disease: Sonographic Criteria Angiology, February 1, 1995; 46(2): 129 - 135. [Abstract] [PDF] |
||||
![]() |
N.H.P. Allen and A. Burns The treatment of Alzheimer's disease J Psychopharmacol, January 1, 1995; 9(1): 43 - 56. [PDF] |
||||
![]() |
B. Giordani, S. Berent, M. J. Boivin, J. B. Penney, S. Lehtinen, D. S. Markel, Z. Hollingsworth, G. Butterbaugh, R. D. Hichwa, J. F. Gusella, et al. Longitudinal Neuropsychological and Genetic Linkage Analysis of Persons at Risk for Huntington's Disease Arch Neurol, January 1, 1995; 52(1): 59 - 64. [Abstract] [PDF] |
||||
![]() |
D. Blacker, M. S. Albert, S. S. Bassett, R. C. P. Go, L. E. Harrell, and M. F. Folstein Reliability and Validity of NINCDS-ADRDA Criteria for Alzheimer's Disease: The National Institute of Mental Health Genetics Initiative Arch Neurol, December 1, 1994; 51(12): 1198 - 1204. [Abstract] [PDF] |
||||
![]() |
J. R. Absher, D. L. Sultzer, M. E. Mahler, and J. Fishman p(C) Analysis Facilitates Dementia Diagnosis Med Decis Making, October 1, 1994; 14(4): 393 - 402. [Abstract] [PDF] |
||||
![]() |
D. Galasko, L. A. Hansen, R. Katzman, W. Wiederholt, E. Masliah, R. Terry, L. R. Hill, P. Lessin, and L. J. Thal Clinical-Neuropathological Correlations in Alzheimer's Disease and Related Dementias Arch Neurol, September 1, 1994; 51(9): 888 - 895. [Abstract] [PDF] |
||||
![]() |
K. F. Mortel, M. A. Pavol, S. Wood, J. S. Meyer, Y. Terayama, J. L. Rexer, and B. Herod Prospective Studies of Cerebral Perfusion and Cognitive Testing Among Elderly Normal Volunteers and Patients with Ischemic Vascular Dementia and Alzheimer's Disease Angiology, March 1, 1994; 45(3): 171 - 180. [Abstract] [PDF] |
||||
![]() |
M. D. Lindner, D. D. Gordon, J. M. Miller, P. N. Tariot, K. D. McDaniel, R. W. Hamill, P. S. DiStefano, and R. Loy Increased Levels of Truncated Nerve Growth Factor Receptor in Urine of Mildly Demented Patients With Alzheimer's Disease Arch Neurol, October 1, 1993; 50(10): 1054 - 1058. [Abstract] [PDF] |
||||
![]() |
B. H. Price, H. Gurvit, S. Weintraub, C. Geula, E. Leimkuhler, and M. Mesulam Neuropsychological Patterns and Language Deficits in 20 Consecutive Cases of Autopsy-Confirmed Alzheimer's Disease Arch Neurol, September 1, 1993; 50(9): 931 - 937. [Abstract] [PDF] |
||||
![]() |
K. F. Mortel, S. Wood, M. A. Pavol, J. S. Meyer, and J. L. Rexer Analysis of Familial and Individual Risk Factors Among Patients with Ischemic Vascular Dementia and Alzheimer's Disease Angiology, August 1, 1993; 44(8): 599 - 605. [Abstract] [PDF] |
||||
![]() |
A. F. Jorm, L. Fratiglioni, and B. Winblad Differential Diagnosis in Dementia: Principal Components Analysis of Clinical Data From a Population Survey Arch Neurol, January 1, 1993; 50(1): 72 - 77. [Abstract] [PDF] |
||||
![]() |
M Shoji, T. Golde, J Ghiso, T. Cheung, S Estus, L. Shaffer, X. Cai, D. McKay, R Tintner, B Frangione, et al. Production of the Alzheimer amyloid beta protein by normal proteolytic processing Science, October 2, 1992; 258(5079): 126 - 129. [Abstract] [PDF] |
||||
![]() |
O. Almkvist, L.-O. Wahlund, G. Andersson-Lundman, H. Basun, and L. Backman White-Matter Hyperintensity and Neuropsychological Functions in Dementia and Healthy Aging Arch Neurol, June 1, 1992; 49(6): 626 - 632. [Abstract] [PDF] |
||||
![]() |
M. S. Buchsbaum, J. P. Kesslak, G. Lynch, H. Chui, J. Wu, N. Sicotte, E. Hazlett, E. Teng, and C. W. Cotman Temporal and Hippocampal Metabolic Rate During an Olfactory Memory Task Assessed by Positron Emission Tomography in Patients With Dementia of the Alzheimer Type and Controls: Preliminary Studies Arch Gen Psychiatry, September 1, 1991; 48(9): 840 - 847. [Abstract] [PDF] |
||||
![]() |
H. Ito, S. Goto, A. Hirano, and S.-H. C. Yen Immunohistochemical Study of the Hippocampus in Parkinsonism-Dementia Complex on Guam J Geriatr Psychiatry Neurol, July 1, 1991; 4(3): 134 - 142. [Abstract] [PDF] |
||||
![]() |
P. B. Davis, H. White, J. L. Price, D. McKeel, and L. N. Robins Retrospective Postmortem Dementia Assessment: Validation of a New Clinical Interview to Assist Neuropathologic Study Arch Neurol, June 1, 1991; 48(6): 613 - 617. [Abstract] [PDF] |
||||
![]() |
K. A. Shay, L. W. Duke, T. Conboy, L. E. Harrell, R. Callaway, and D. G. Folks The Clinical Validity of the Mattis Dementia Rating Scale in Staging Alzheimer's Dementia J Geriatr Psychiatry Neurol, January 1, 1991; 4(1): 18 - 25. [Abstract] [PDF] |
||||
![]() |
M. F. Mendez, A. R. Mastri, J.H. Sung, B. A. Zander, and W. H. Frey Neuropathologically Confirmed Alzheimer's Disease: Clinical Diagnoses in 394 Cases J Geriatr Psychiatry Neurol, January 1, 1991; 4(1): 26 - 29. [Abstract] [PDF] |
||||
![]() |
J. Whitson, D. Selkoe, and C. Cotman Amyloid beta protein enhances the survival of hippocampal neurons in vitro Science, March 17, 1989; 243(4897): 1488 - 1490. [Abstract] [PDF] |
||||
![]() |
W. A. Marks, R. M. Shuman, R. W. Leech, and R. A. Brumback Cerebral Degenerations Producing Dementia: Importance of Neuropathologic Confirmation of Clinical Diagnoses J Geriatr Psychiatry Neurol, October 1, 1988; 1(4): 187 - 198. [Abstract] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |