Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tierney, M. C.
Right arrow Articles by Nieuwstraten, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tierney, M. C.
Right arrow Articles by Nieuwstraten, P.
NEUROLOGY 1988;38:359
© 1988 American Academy of Neurology

The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease

A clinicopathologic study of 57 cases

Mary C. Tierney, PhD, Rory H. Fisher, MB, Anthony J. Lewis, MD, Maria L. Zorzitto, MD, W. Gary Snow, PhD, David W. Reid, PhD and Paula Nieuwstraten, MD

From the Geriatric Research Programme and the Departments of Psychology, Extended Care, and Pathology, Sunnybrook Medical Centre, University of Toronto, Toronto, Ontario, Canada.

Neuropathologic confirmation is required to validate the NINCDS-ADRDA Work Group criteria for the clinical diagnosis of Alzheimer's disease (AD). Neuropathologic inclusion and exclusion criteria for AD, however, are not uniform. The purpose of this investigation was to examine the confirmation rate for the Work Group criteria against differing neuropathologic criteria for AD. The sample consisted of 57 cases, 22 of which had received a clinical diagnosis of AD. Nine neuropathologic criteria for AD were applied in a blind fashion to each of the 57 cases. Our results indicated that, depending on the neuropathologic criteria applied, the clinicopathologic agreement ranged from 64% to 86%. These findings demonstrate the need for universally accepted neuropathologic and clinical criteria for AD.

Address correspondence and reprint requests to Dr. Tierney, Geriatric Research Programme, Sunnybrook Medical Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.

Supported by the Ontario Ministry of Health, the Gerontology Research Council of Ontario, the Canadian Geriatric Research Society, and the Sunnybrook Medical Centre Research Fund.

Received March 25, 1987. Accepted for publication in final form June 10, 1987.




This article has been cited by other articles:


Home page
 Am. J. Neuroradiol.Home page
F.L. Giesel, H.K. Hahn, P.A. Thomann, E. Widjaja, E. Wignall, H. von Tengg-Kobligk, J. Pantel, P.D. Griffiths, H.O. Peitgen, J. Schroder, et al.
Temporal Horn Index and Volume of Medial Temporal Lobe Atrophy Using a New Semiautomated Method for Rapid and Precise Assessment
AJNR Am. J. Neuroradiol., August 1, 2006; 27(7): 1454 - 1458.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
L. L. Chao, N. Schuff, J. H. Kramer, A. T. Du, A. A. Capizzano, J. O'Neill, O. M. Wolkowitz, W. J. Jagust, H. C. Chui, B. L. Miller, et al.
Reduced medial temporal lobe N-acetylaspartate in cognitively impaired but nondemented patients
Neurology, January 25, 2005; 64(2): 282 - 289.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
N. Schuff, A.A. Capizzano, A.T. Du, D.L. Amend, J. O'Neill, D. Norman, W.J. Jagust, H.C. Chui, J.H. Kramer, B.R. Reed, et al.
Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD
Neurology, August 12, 2003; 61(3): 358 - 364.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J J Kril, S Patel, A J Harding, and G M Halliday
Patients with vascular dementia due to microvascular pathology have significant hippocampal neuronal loss
J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 747 - 751.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
N. Schuff, A. A. Capizzano, A. T. Du, D. L. Amend, J. O'Neill, D. Norman, J. Kramer, W. Jagust, B. Miller, O. M. Wolkowitz, et al.
Selective reduction of N-acetylaspartate in medial temporal and parietal lobes in AD
Neurology, March 26, 2002; 58(6): 928 - 935.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. Padovani, L. Pastorino, B. Borroni, F. Colciaghi, L. Rozzini, R. Monastero, J. Perez, C. Pettenati, M. Mussi, G. Parrinello, et al.
Amyloid precursor protein in platelets: A peripheral marker for the diagnosis of sporadic AD
Neurology, December 26, 2001; 57(12): 2243 - 2248.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. Petrovitch, L.R. White, G.W. Ross, S.C. Steinhorn, C.Y. Li, K.H. Masaki, D.G. Davis, J. Nelson, J. Hardman, J.D. Curb, et al.
Accuracy of clinical criteria for AD in the Honolulu-Asia Aging Study, a population-based study
Neurology, July 24, 2001; 57(2): 226 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
N. Andreasen, L. Minthon, P. Davidsson, E. Vanmechelen, H. Vanderstichele, B. Winblad, and K. Blennow
Evaluation of CSF-tau and CSF-A{beta}42 as Diagnostic Markers for Alzheimer Disease in Clinical Practice
Arch Neurol, March 1, 2001; 58(3): 373 - 379.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
J. M. Hoffman, K. A. Welsh-Bohmer, M. Hanson, B. Crain, C. Hulette, N. Earl, and R. E. Coleman
FDG PET Imaging in Patients with Pathologically Verified Dementia
J. Nucl. Med., November 1, 2000; 41(11): 1920 - 1928.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
N. Andreasen, L. Minthon, A. Clarberg, P. Davidsson, J. Gottfries, E. Vanmechelen, H. Vanderstichele, B. Winblad, and K. Blennow
Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample
Neurology, October 22, 1999; 53(7): 1488 - 1488.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
M. S. Nobler, G. H. Pelton, and H. A. Sackeim
Cerebral Blood Flow and Metabolism in Late-Life Depression and Dementia
J Geriatr Psychiatry Neurol, October 1, 1999; 12(3): 118 - 127.
[Abstract] [PDF]

Home page
 NeurologyHome page
O. L. Lopez, I. Litvan, K. E. Catt, R. Stowe, W. Klunk, D. I. Kaufer, J. T. Becker, and S. T. DeKosky
Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias
Neurology, October 1, 1999; 53(6): 1292 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
K. Juottonen, M. P. Laakso, K. Partanen, and H. Soininen
Comparative MR Analysis of the Entorhinal Cortex and Hippocampus in Diagnosing Alzheimer Disease
AJNR Am. J. Neuroradiol., January 1, 1999; 20(1): 139 - 144.
[Abstract] [Full Text]

Home page
 Arch NeurolHome page
D. Galasko, L. Chang, R. Motter, C. M. Clark, J. Kaye, D. Knopman, R. Thomas, D. Kholodenko, D. Schenk, I. Lieberburg, et al.
High Cerebrospinal Fluid Tau and Low Amyloid {beta}42 Levels in the Clinical Diagnosis of Alzheimer Disease and Relation to Apolipoprotein E Genotype
Arch Neurol, July 1, 1998; 55(7): 937 - 945.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
J. V Bowler, D. G Munoz, H. Merskey, and V. Hachinski
Fallacies in the pathological confirmation of the diagnosis of Alzheimer's disease
J. Neurol. Neurosurg. Psychiatry, January 1, 1998; 64(1): 18 - 24.
[Abstract] [Full Text]

Home page
 AM J ALZHEIMERS DIS OTHER DEMENHome page
J. Shua-Haim, G. Koppuzha, V. Shua-Haim, and J. Gross
A simple score system for clock drawing in patients with Alzheimer's disease
American Journal of Alzheimer's Disease and Other Dementias, September 1, 1997; 12(5): 212 - 215.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
G. Li, M. Aryan, J. M. Silverman, V. Haroutunian, D. P. Perl, S. Birstein, M. Lantz, D. B. Marin, R. C. Mohs, and K. L. Davis
The Validity of the Family History Method for Identifying Alzheimer Disease
Arch Neurol, May 1, 1997; 54(5): 634 - 640.
[Abstract] [PDF]

Home page
 ANGIOLOGYHome page
K. F. Mortel and J. S. Meyer
Prospective Study of Vascular Events and Cerebral Perfusional Chang Following Transient Ischemic Attacks
Angiology, March 1, 1996; 47(3): 215 - 224.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
L. A. Klatka, R. B. Schiffer, J. M. Powers, and A. M. Kazee
Incorrect Diagnosis of Alzheimer's Disease: A Clinicopathologic Study
Arch Neurol, January 1, 1996; 53(1): 35 - 42.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
H. A. Crystal, D. Dickson, M. Sliwinski, D. Masur, A. Blau, and R. B. Lipton
Associations of Status and Change Measures of Neuropsychological Function With Pathologic Changes in Elderly, Originally Nondemented Subjects
Arch Neurol, January 1, 1996; 53(1): 82 - 87.
[Abstract] [PDF]

Home page
 StrokeHome page
T. Wetterling, R.-D. Kanitz, and K.-J. Borgis
Comparison of Different Diagnostic Criteria for Vascular Dementia (ADDTC, DSM-IV, ICD-10, NINDS-AIREN)
Stroke, January 1, 1996; 27(1): 30 - 36.
[Abstract] [Full Text]

Home page
 ANGIOLOGYHome page
S. Biedert, H. Forstl, and W. Hewer
Multiinfarct Dementia vs Alzheimer's Disease: Sonographic Criteria
Angiology, February 1, 1995; 46(2): 129 - 135.
[Abstract] [PDF]

Home page
 J PsychopharmacolHome page
N.H.P. Allen and A. Burns
The treatment of Alzheimer's disease
J Psychopharmacol, January 1, 1995; 9(1): 43 - 56.
[PDF]

Home page
 Arch NeurolHome page
B. Giordani, S. Berent, M. J. Boivin, J. B. Penney, S. Lehtinen, D. S. Markel, Z. Hollingsworth, G. Butterbaugh, R. D. Hichwa, J. F. Gusella, et al.
Longitudinal Neuropsychological and Genetic Linkage Analysis of Persons at Risk for Huntington's Disease
Arch Neurol, January 1, 1995; 52(1): 59 - 64.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
D. Blacker, M. S. Albert, S. S. Bassett, R. C. P. Go, L. E. Harrell, and M. F. Folstein
Reliability and Validity of NINCDS-ADRDA Criteria for Alzheimer's Disease: The National Institute of Mental Health Genetics Initiative
Arch Neurol, December 1, 1994; 51(12): 1198 - 1204.
[Abstract] [PDF]

Home page
 Med Decis MakingHome page
J. R. Absher, D. L. Sultzer, M. E. Mahler, and J. Fishman
p(C) Analysis Facilitates Dementia Diagnosis
Med Decis Making, October 1, 1994; 14(4): 393 - 402.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
D. Galasko, L. A. Hansen, R. Katzman, W. Wiederholt, E. Masliah, R. Terry, L. R. Hill, P. Lessin, and L. J. Thal
Clinical-Neuropathological Correlations in Alzheimer's Disease and Related Dementias
Arch Neurol, September 1, 1994; 51(9): 888 - 895.
[Abstract] [PDF]

Home page
 ANGIOLOGYHome page
K. F. Mortel, M. A. Pavol, S. Wood, J. S. Meyer, Y. Terayama, J. L. Rexer, and B. Herod
Prospective Studies of Cerebral Perfusion and Cognitive Testing Among Elderly Normal Volunteers and Patients with Ischemic Vascular Dementia and Alzheimer's Disease
Angiology, March 1, 1994; 45(3): 171 - 180.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
M. D. Lindner, D. D. Gordon, J. M. Miller, P. N. Tariot, K. D. McDaniel, R. W. Hamill, P. S. DiStefano, and R. Loy
Increased Levels of Truncated Nerve Growth Factor Receptor in Urine of Mildly Demented Patients With Alzheimer's Disease
Arch Neurol, October 1, 1993; 50(10): 1054 - 1058.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
B. H. Price, H. Gurvit, S. Weintraub, C. Geula, E. Leimkuhler, and M. Mesulam
Neuropsychological Patterns and Language Deficits in 20 Consecutive Cases of Autopsy-Confirmed Alzheimer's Disease
Arch Neurol, September 1, 1993; 50(9): 931 - 937.
[Abstract] [PDF]

Home page
 ANGIOLOGYHome page
K. F. Mortel, S. Wood, M. A. Pavol, J. S. Meyer, and J. L. Rexer
Analysis of Familial and Individual Risk Factors Among Patients with Ischemic Vascular Dementia and Alzheimer's Disease
Angiology, August 1, 1993; 44(8): 599 - 605.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
A. F. Jorm, L. Fratiglioni, and B. Winblad
Differential Diagnosis in Dementia: Principal Components Analysis of Clinical Data From a Population Survey
Arch Neurol, January 1, 1993; 50(1): 72 - 77.
[Abstract] [PDF]

Home page
 ScienceHome page
M Shoji, T. Golde, J Ghiso, T. Cheung, S Estus, L. Shaffer, X. Cai, D. McKay, R Tintner, B Frangione, et al.
Production of the Alzheimer amyloid beta protein by normal proteolytic processing
Science, October 2, 1992; 258(5079): 126 - 129.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
O. Almkvist, L.-O. Wahlund, G. Andersson-Lundman, H. Basun, and L. Backman
White-Matter Hyperintensity and Neuropsychological Functions in Dementia and Healthy Aging
Arch Neurol, June 1, 1992; 49(6): 626 - 632.
[Abstract] [PDF]

Home page
 Arch Gen PsychiatryHome page
M. S. Buchsbaum, J. P. Kesslak, G. Lynch, H. Chui, J. Wu, N. Sicotte, E. Hazlett, E. Teng, and C. W. Cotman
Temporal and Hippocampal Metabolic Rate During an Olfactory Memory Task Assessed by Positron Emission Tomography in Patients With Dementia of the Alzheimer Type and Controls: Preliminary Studies
Arch Gen Psychiatry, September 1, 1991; 48(9): 840 - 847.
[Abstract] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
H. Ito, S. Goto, A. Hirano, and S.-H. C. Yen
Immunohistochemical Study of the Hippocampus in Parkinsonism-Dementia Complex on Guam
J Geriatr Psychiatry Neurol, July 1, 1991; 4(3): 134 - 142.
[Abstract] [PDF]

Home page
 Arch NeurolHome page
P. B. Davis, H. White, J. L. Price, D. McKeel, and L. N. Robins
Retrospective Postmortem Dementia Assessment: Validation of a New Clinical Interview to Assist Neuropathologic Study
Arch Neurol, June 1, 1991; 48(6): 613 - 617.
[Abstract] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
K. A. Shay, L. W. Duke, T. Conboy, L. E. Harrell, R. Callaway, and D. G. Folks
The Clinical Validity of the Mattis Dementia Rating Scale in Staging Alzheimer's Dementia
J Geriatr Psychiatry Neurol, January 1, 1991; 4(1): 18 - 25.
[Abstract] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
M. F. Mendez, A. R. Mastri, J.H. Sung, B. A. Zander, and W. H. Frey
Neuropathologically Confirmed Alzheimer's Disease: Clinical Diagnoses in 394 Cases
J Geriatr Psychiatry Neurol, January 1, 1991; 4(1): 26 - 29.
[Abstract] [PDF]

Home page
 ScienceHome page
J. Whitson, D. Selkoe, and C. Cotman
Amyloid beta protein enhances the survival of hippocampal neurons in vitro
Science, March 17, 1989; 243(4897): 1488 - 1490.
[Abstract] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
W. A. Marks, R. M. Shuman, R. W. Leech, and R. A. Brumback
Cerebral Degenerations Producing Dementia: Importance of Neuropathologic Confirmation of Clinical Diagnoses
J Geriatr Psychiatry Neurol, October 1, 1988; 1(4): 187 - 198.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by AAN Enterprises, Inc.