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Clomiphene therapy in epileptic women with menstrual disorders

From the Neuroendocrine Section, Neurological Unit, Charles A. Dana Research Institute, Beth Israel Hospital, and the Department of Neurology, Harvard Medical School, Boston, MA.

We studied the effects of clomiphene therapy on seizure frequency in 12 women who had clinical and EEG features of complex partial seizures as well as menstrual disorders with reproductive endocrine abnormalities. Ten of the 12 women improved (p < 0. 05); all ten developed normal cycles. The two women who did not improve continued to have irregular prolonged cycles. Average monthly seizure frequency for the entire group declined by 87% (p < 0. 01). Both complex partial and secondary generalized seizures decreased. During the investigation, one unwanted pregnancy occurred, two women developed severe abdominal pain with ultrasound-documented ovarian cysts, and three experienced breast tenderness and pelvic cramps.

Address correspondence and reprint requests to Dr. Herzog, Neurological Unit, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215.

Presented in part at the thirty-ninth annual meeting of the American Academy of Neurology, New York, NY, April 1987.

Received May 29, 1987. Accepted for publication in final form July 2, 1987.

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