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Protein redistribution diet restores motor function in patients with dopa-resistant "off" periods

From Yale University School of Medicine, Department of Neurology, New Haven, CT.

Sixteen parkinsonians with acquired drug-resistant "off" periods without dyskinesia were placed on a diet in which virtually all protein was concentrated in the evening meal. Restoration of sensitivity to levodopa resulted in 88%. Ten patients (62%) have continued to comply with the diet for 7 months (mean). Two patients were studied in detail. Immobility correlated with elevated plasma levels of large neutral amino acids (LNAA), normality with low LNAA.

Address correspondence and reprint requests to Dr. Pincus, Professor and Chairman, Department of Neurology, Georgetown University School of Medicine, Washington, DC 20007.

Supported in part by grants from the J. M. Foundation and the Lowenstein Foundation.

Received February 24, 1987. Accepted for publication in final form June 3, 1987.

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