HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mollman, J. E. Articles by McCluskey, L. F. Search for Related Content PubMed PubMed Citation Articles by Mollman, J. E. Articles by McCluskey, L. F.

Unusual presentation of cis-platinum Neuropathy

From the Departments of Neurology (Drs. Mollman and McCluskey), Obstetrics and Gynecology (Dr. Hogan), and Medicine (Dr. Glover), Division of Hematology-Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA.

Symptoms and signs of cis-diamminedichloroplatinum II (DDP) neuropathy usually develop during treatment and stabilize or improve when DDP is stopped. We report three patients whose symptoms began 3 to 8 weeks after the last dose of DDP and progressed over 1 or 2 months to moderate-marked disability. The clinical picture in each was consistent with DDP neuropathy, and no other cause could be identified. Two of the patients improved over 8 and 27 months to become asymptomatic; the other died 2 months after presentation. It is important to recognize that DDP neuropathy can present after treatment has been discontinued since the clinical picture mimics the para-neoplastic dorsal root ganglionitis, which has a different prognosis.

Address correspondence and reprint requests to Dr. Mollman, Department of Neurology, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104.

Dr. Mollman is the recipient of NINCDS Teacher-Investigator Award #NS00563.

Presented in part at the thirty-seventh annual meeting of the American Academy of Neurology, Dallas, TX, April 1985.

Received February 4, 1987. Accepted for publication in final form June 3, 1987.

This article has been cited by other articles:

				O. Heinzlef, J.-P. Lotz, and E. Roullet Severe neuropathy after high dose carboplatin in three patients receiving multidrug chemotherapy J. Neurol. Neurosurg. Psychiatry, May 1, 1998; 64(5): 667 - 669. [Abstract] [Full Text] [PDF]