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NEUROLOGY 1988;38:550
© 1988 American Academy of Neurology

Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication

H. B. Ferraz, MD, P. H. F. Bertolucci, PhD, J. S. Pereira, MD, J.G.C. Lima, MD and L. A. F. Andrade, PhD

From the Division of Extrapyramidal Diseases Investigation, Department of Neurology and Neurosurgery, Escola Paulista de Medicine, Sào Paulo, Brazil.

Manganese (Mn) poisoning, a well-known hazard in miners and industrial workers, shares many features with Parkinson's disease. Two young agricultural workers with a parkinsonian syndrome, who mentioned exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate), led us to investigate a new possible source of Mn intoxication. Fifty male rural workers with occupational exposure to maneb were compared with 19 rural workers without fungicide exposure. We noted significantly higher prevalence of plastic rigidity with cogwheel phenomenon, headache, fatigue, nervousness, memory complaints, and sleepiness in the exposed group. In addition, we saw other neurologic signs, such as postural tremor, cerebellar signs, and bradykinesia, although without statistical significance. The data suggest that occupational exposure to pesticides containing Mn is a possible source of Mn intoxication of the CNS.

Address correspondence and reprint requests to Dr. Andrade, R. Borges Lagoa, 1231 CJ.44, CEP 04038, Sào Paulo, Brazil.

Received April 14, 1987. Accepted for publication in final form August 21, 1987.




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