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NEUROLOGY 1988;38:580
© 1988 American Academy of Neurology

Myasthenia gravis and primary squamous cell carcinoma of the thymus

A case report

Francis J. DiMario, Jr., MD, Robert P. Lisak, MD, Michael J. Kornstein, MD and John J. Brooks, MD

From the Departments of Neurology (Drs. DiMario and Lisak) and Pathology and Laboratory Medicine (Drs. Kornstein and Brooks), University of Pennsylvania School of Medicine, Philadelphia, PA.

We detail a case of primary squamous cell carcinoma of the thymus in a patient with myasthenia gravis. The clinical course of the patient and the gross and histologic appearance of the thymus are discussed. Appropriate therapy for patients with these tumors includes resection of the tumor followed by radiation therapy and continued surveillance for recurrence. Review of the literature indicates less than 50% survival at 10 years and 22% recurrence rate at 5 years for patients with this tumor.

Address correspondence and reprint requests to Dr. DiMario, Department of Neurology, The Children's Hospital of Philadelphia, One Children's Center, 34th Street & Civic Center Boulevard, Philadelphia, PA 19104.

Received May 13, 1987. Accepted for publication in final form July 31, 1987.






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