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Rare Ha-ras and c-mos alleles in patients with intracranial tumors

From the University Neurology Clinic (Dr. Diedrich), and the Institute of Human Genetics (Drs. Eckermann and Schmidtke), Göttingen, West Germany.

The occurrence of rare hypervariable Ha-ras alleles or of a rare c-mos allele in white blood cell DNA is claimed to be associated with susceptibility to cancer. We analyzed a group of patients with intracranial tumors to determine whether the occurrence of rare alleles at the Ha-ras locus and at the c-mos locus was increased in comparison with normal individuals. We found a higher incidence of rare hypervariable Ha-ras alleles (9.5% to 3%) and a 5 kilobase EcoRI c-mos allele (2.5% to 0%) in the patients. These results are consistent with the opinion that such unusual alleles are associated with a predisposition to intracranial tumors.

Address correspondence and reprint requests to Dr. Diedrich, University Neurology Clinic, Robert-Koch-Strasse 40, D-3400 Göttingen, West Germany.

Supported by a grant of the Deutsche Forschungsgemeinschaft to U.D.

Received May 21, 1987. Accepted for publication in final form July 27, 1987.

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