Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Machi, M.
Right arrow Articles by Kuroiwa, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Machi, M.
Right arrow Articles by Kuroiwa, Y.
NEUROLOGY 1988;38:592
© 1988 American Academy of Neurology

Surface phenotypes of lymphoid cells altered in the human myasthenic thymus

Michi Machi, MD, Yasuto Itoyama, MD, Ikuo Goto, MD and Yoshigoro Kuroiwa, MD

From the Department of Neurology, Neurological Institute, Kyushu University, Fukuoka, Japan.

We investigated surface phenotypes of peripheral blood lymphocytes and thymic lymphoid cells from patients with myasthenia gravis (MG) by fluorocytometry, using monoclonal antibodies to human lymphoid cells. There were no significant differences in peripheral blood lymphocyte subsets in myasthenic patients, with or without a thymus. In the MG hyperplastic thymuses, the percentage of OKIal+ cells or CCB1+ cells was significantly increased compared with controls. Although there were no significant differences in the percentage of T-cell lineage (CD3 +, CD4+, CD8+, or CD1+ cells) between MG hyperplastic thymuses and the controls, the surface densities of T-cell lineage antigens (CD3, CD4, and CD8) were significantly increased on lymphoid cells in MG hyperplastic thymuses, compared with those in control thymuses. There were no significant differences in the percentage or fluorocytograph of lymphoid cells between the MG thymomas and the controls.

Address correspondence and reprint requests to Dr. Itoyama, Department of Neurology, Neurological Institute, Kyushu University 60, Fukuoka 812, Japan.

Supported by grants from the Neuroimmunological Disease Research Committee, The Ministry of Health and Welfare of Japan.

Received May 29, 1987. Accepted for publication in final form August 12, 1987.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1988 by AAN Enterprises, Inc.