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NEUROLOGY 1988;38:614
© 1988 American Academy of Neurology

Specific antibody activity against neuroendocrine tissue in a case of POEMS syndrome with IgG gammopathy

Monika Reulecke, MD, Marc Dumas, PhD and Claus Meier, MD

From the Department of Neurology, University of Bern, Bern, Switzerland.

Specific antibody binding activity directed against pituitary tissue was demonstrated in a typical case of POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) syndrome with paraproteinemia of IgG lambda type. IgG binding against various other tissues could not be detected by immunoelectroblotting and immunocytochemistry. We propose that POEMS syndrome is an antibody-mediated immune disorder, in which the hypophysis is the primary target of the pathologic myeloma antibodies. The immunopathogenetic lesion of the hypophysis could induce secondary disturbances of other organs, thus explaining the multisystemic disorder.

Address correspondence and reprint requests to Prof. Meier, Universitat Bern, Neurologische Klinik, Inselspital, CH-3010 Bern, Switzerland.

Supported by the Swiss Multiple Sclerosis Society.

Received January 27, 1987. Accepted for publication in final form August 25, 1987.




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