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NEUROLOGY 1988;38:617
© 1988 American Academy of Neurology

Epidemiology of multiple sclerosis in London and Middlesex County, Ontario, Canada

Walter J. Hader, MD, Margaret Elliot, BScN and George C. Ebers, MD

From the Department of Clinical Neurological Sciences, University of Western Ontario, University Hospital, London, Ontario, and the Rehabilitation Department, University of Saskatchewan, University Hospital, Saskatoon, Saskatchewan, Canada.

A case-controlled epidemiologic study of multiple sclerosis (MS) was carried out in London, Ontario, and its surrounding Middlesex County for the period 1974–1983. The prevalence rates for clinically definite/probable MS on January 1, 1984 were 94/100,000 for the city and 91/100,000 for the county. The estimated annual incidence rate for the decade 1974–83 was 3.4/100,000. The female-to-male sex ratio was 2.5:1. A familial history of MS was recorded in 14.4% of close relatives and a total of 17% when distant relatives are included. The MS group is predominantly of British (70%) and European (23%) origin. The urban-rural residence pattern analysis indicates no significant regional influence on the risk of developing MS.

Address correspondence and reprint requests to Dr. Hader, Rehabilitation Department, University Hospital, Saskatoon, Saskatchewan, S7N 0X0, Canada.

Supported by the Multiple Sclerosis Society of Canada.

Received May 5, 1986. Accepted for publication in final form July 29, 1987.




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