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From the Department of Neurology (Dr. Whitehouse), Case Western Reserve University and Alzheimer Center, University Hospitals of Cleveland, Cleveland, OH; the Departments of Neurology and Neuroscience (Dr. Price) and the Neuropathology Laboratory, Department of Pathology (Drs. Wagster and Price), The Johns Hopkins University School of Medicine, Baltimore, MD; Georgetown University School of Medicine and Dentistry (Ms. Martino), Washington, DC; the Department of Neurology (Dr. Mayeux), Columbia University, New York, NY; the Laboratory of Neuroscience (Dr. Atack), National Institute on Aging, Washington, DC; and the Department of Pharmacology (Dr. Kellar), Georgetown University School of Medicine and Dentistry, Washington, DC.
In Alzheimer's disease (AD) and Parkinson's disease (PD), dysfunction in the basal forebrain cholinergic system is accompanied by a consistent loss of presynaptic cholinergic markers in cortex, but changes in cholinergic receptor binding sites are poorly understood. In the present study, we used receptor autoradiography to map the distribution of nicotinic [3H]acetylcholine binding sites in cortices of individuals with AD and PD and matched control subjects. In both diseases, a profound loss of nicotinic receptors occurs in all cortical layers, particularly the deepest layers.
Address correspondence and reprint requests to Dr. Whitehouse, University Hospitals of Cleveland, Alzheimer Center, 2074 Abington Road, Cleveland, OH 44106.
Supported by funds from the US Public Health Service (NIH AG 05146, AG 03359, and NS 20471), US Army MRDC (DAMD 17-83-C-3113), as well as fellowships from the Sloan Foundation, McKnight Foundation, and the Commonwealth Fund.
Received June 11, 1987. Accepted for publication in final form September 3, 1987.
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