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Prevalence of multiple sclerosis in the Parsis of Bombay

From the Departments of Neuroepidemiology (Drs. N. Bharucha, E. Bharucha, A. Bharucha, and Ms. Bhise) and Neurology (Dr. Singhal), Bombay Hospital, Medical Research Center, Bombay; the Department of Neurology (Drs. N. Bharucha and E.P. Bharucha), K.E.M. Hospital and Seth G.S. Medical College, Bombay; the Department of Neurology (Dr. Wadia), Jaslok Hospital and Research Centre, Bombay; the Department of Neurology (Drs. Wadia and Singhal), J.J. Group of Hospitals and Grant Medical College, Bombay, India; the Neuroepidemiology Research Program and the Neurology Service (Dr. Kurtzke), Veterans Administration Medical Center, and the Departments of Neurology and Community Medicine, Georgetown University School of Medicine, Washington, DC; and the Neuroepidemiology Branch (Dr. Schoenberg), National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD.

We carried out a door-to-door-survey to screen a community of 14,010 people (Parsis living in colonies in Bombay, India) for possible neurologic diseases, and used defined diagnostic criteria to evaluate people who tested positive on the screening survey. There were three clinically definite cases of multiple sclerosis (21/100,000). This is the first prevalence survey for multiple sclerosis in a large developing country.

Address correspondence to Dr. N.E. Bharucha, Neuroepidemiology Department, Bombay Hospital, Medical Research Center, 12 Marine Lines, Bombay, India, 400020. Address reprint requests to the Chief, Neuroepidemiology Branch, NINCDS, NIH, Federal Building Room 804, 7550 Wisconsin Avenue, Bethesda, MD 20892.

Supported by the Rameshwardas Birla Smarak Kosh, Bombay, India; Trustees of the Parsi Punchayet Funds and Properties, Bombay, India; the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA, and the P.C. Bharucha Trust, Bombay, India.

Received May 29, 1987. Accepted for publication in final form September 3, 1987.

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